Influence of leptin and adiponectin on prostate cancer.

LÓPEZ FONTANA C.; DI MILTA N; MASELLI ME.; RECALDE GM.; VANRELL MC.; PÉREZ ELIZALDE R.; LÓPEZ LAUR JD.

ARCHIVOS ESPANOLES DE UROLOGIA.

Bok S. A.

Año: 2009 vol. 62 p. 103 - 108

0004-0614

Influence of leptin and adiponectin on prostate cancer. Many studies have investigated the association between obesity, adipose tissue-derived factors (leptin and adiponectin) and prostate cancer (CaP) but the results are still inconsistent. METHODS: The aim of this study was to carry out a comprehensive review of the existing evidence about the role of leptin and adiponectin in prostate carcinogenesis and to provide an overview of it. RESULTS: Recent evidence suggests that leptin may play a rol in prostate cancer progression, while adiponectin may act as an "antiprostatic cancer" adipokine. CONCLUSIONS: Obesity may promote the progression of established prostate cancer and and adipokines may provide a molecular mechanism whereby obesity exerts its effects on prostate tumour biology.