INVESTIGADORES
PICCIONI Flavia Valeria
artículos
Título:
Cancer-Associated Fibroblasts in the Breast Tumor Microenvironment
Autor/es:
GIORELLO, MARÍA BELÉN; BORZONE, FRANCISCO RAÚL; LABOVSKY, VIVIAN; PICCIONI, FLAVIA VALERIA; CHASSEING, NORMA ALEJANDRA
Revista:
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Editorial:
SPRINGER/PLENUM PUBLISHERS
Referencias:
Año: 2021
ISSN:
1083-3021
Resumen:
Years of investigation have shed light on a theory in which breast tumor epithelial cells are under the effect of the stromal microenvironment. This review aims to discuss recent findings concerning the phenotypic and functional characteristics of cancer associated fibroblasts (CAFs) and their involvement in tumor evolution, as well as their potential implications for anti-cancer therapy. In this manuscript, we reviewed that CAFs play a fundamental role in initiation, growth, invasion, and metastasis of breast cancer, and also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of this disease.
