INVESTIGADORES
GOSZCZYNSKI Daniel Estanislao
congresos y reuniones científicas
Título:
Candidate gene for age at puberty in Angus bulls: association study targeting 41 candidate genes with 69 SNPs
Autor/es:
FERNANDEZ M. E.; LIRON J. P.; PRANDO A.; GOSZCZYNSKI D. E.; ROGBERG MUÑOZ A.; PERAL GARCIA P.; BALDO A.; GIOVAMBATTISTA G.
Reunión:
Congreso; 34th Conference of the International Society of Animal Genetics (ISAG); 2014
Resumen:
In
bovine, there are significant differences among and within breeds in the time
when bulls reach puberty. Reported data indicate that age at puberty has a strong
genetic component and is a multigenic trait. However, despite the significant
advancements in the field, the gene network controlling puberty is very
complex, containing a host of genes that exert their effect on the
hypothalamic-pituitary-gonadal (HPG) axis, and several aspects
of regulation of the HPG axis are yet to be fully elucidated. The
objective of this work was to associate 69 SNPs from 41 candidate genes,belonging
to lipid metabolism and growth pathways, with age at puberty in bulls. Angus
males (N = 276) were weighted and scrotal circumference measured every month.
When the first bull calves reached 26 cm of scrotal circumference, sperm
quality was added to the monthly measurements for the next three months. The
SNPs were genotyped using SEQUENOM technology and the
obtained genotypes were associated with four estimated age at puberty (age at
scrotal circumference 28 cm?SC28-, age at sperm concentration 50 million -C50-,
age at 10% of progressive motility ?M10-, age at C50 + M10). Results showed
that SNPrs110383592 in FABP4was
associated with SC28, while a novel SNP in PPARG
5´UTR region was associated with C50. In addition, four SNPs located in 3´UTR
region of TG genewere significant
associated with age at puberty estimated at C50.Further analysis in independent
populations would be necessary to validatethese associations, and to confirm the role of these genes in the onset of bull puberty.
The results obtained could contribute to the understanding of puberty
regulation.