Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina

ADAMS, MARK D.; PASTERAN, FERNANDO; TRAGLIA, GERMAN M.; MARTINEZ, JASMINE; HUANG, FANNY; LIU, CHRISTINE; FERNANDEZ, JENNIFER S.; LOPEZ, CAROLINA; GONZALEZ, LISANDRO J.; ALBORNOZ, EZEQUIEL; CORSO, ALEJANDRA; VILA, ALEJANDRO J.; BONOMO, ROBERT A.; RAMIREZ, MARIA SOLEDAD

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

AMER SOC MICROBIOLOGY

Lugar: Washington; Año: 2020 vol. 64

0066-4804

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying bla NDM-1 Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. bla NDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying bla PER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.