DYNAMICS OF SOLUBLE IMMUNE MEDIATORS IN COVID-19 PATIENTS FROM AN ARGENTINEAN COHORT WITH MODERATE AND SEVERE SYMPTOMS.

ALMADA, L *; ANGIOLINI, SC *; DHO, N *; DUTTO, J *; GAZZONI, Y *; MANZONE, C *; MARIN, C *; PONCE, NE; IRIBARREN, P; CERBAN, F; AMEZCUA VESELY, C; ANA, Y; CERVI, L; CHIAPELLO, L; FOZZATTI, L; ICELY, P; MACCIONI, M; MENA, C; MONTES, C; MOTRAN, C; RODRIGUEZ GALAN, MC; STEMPIN, C; VIANO, ME; BERTONE, M; ESCUDERO, D; ABIEGA, C; KAHN, A; CAEIRO, JP; ARROYO, D; MALETTO, B; ACOSTA RODRIGUEZ, EV; GRUPPI, A; SOTOMAYOR, C; GRUPO IMMUNOCOVIDCBA.

Congreso; Reunión de Sociedades de Biociencias 2021 - LXIX REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA; 2021

*All these authors contributed equally.The cytokine storm, a form of systemic inflammatory response syndrome, is one of the most dreadful complications that can occur during COVID-19. In this work, we aimed at studying the occurrence of a cytokine storm in a cohort of COVID-19 patients (Cpts) from Córdoba (Argentine). During first wave, we collected sera from individuals with RT-PCR+ for SARS-CoV2 hospitalized in Hospital Privado with moderate (MOD) and severe (SEV) disease (n=62, aged 21-80 years) as well as healthy controls (HC n=24, age matched), to determine the concentrations of IL-1b, IL-6, IL-8, IL-10, IL-12, IL-28A/B, IL-29, TNF, IP-10, IFNa2, IFNb, IFNg and GM-CSF by LEGENDplexTM.Males represented 74% of MOD and 67% of SEV Cpts. Hypertension (HT, 48%), obesity (31%), dyslipidemia (DL, 24%), and diabetes (24%) were the most frequent comorbidities. All cytokines,except IL-28A/B, were significantly increased in total Cpts in comparison with HC (p