TRYPANOSOMA CRUZI INFECTION AS AN UNDERLYING FACTOR CATALYZING THE ONSET OF HEMODYNAMIC PERTURBATIONS AND CARDIOVASCULAR DISEASES

VOLPINI, X; QUIROZ, JN; HERRERA, MR; HELLRIEGEL, MF; BRUGO, MB; MUSRI, M; FOZZATTI, L; STEMPIN. CC; PEREZ, AR; MOTRAN, CC

San Luis

Congreso; LXXI Reunión Científica Anual de la Sociedad Argentina de Inmunología.; 2023

Sociedad Argentina de Inmunología

According to the World Health Organization, cardiovascular diseases (CVD) arethe leading global cause of death. Chagas disease (CD), caused by Trypanosomacruzi (TC) infection, is considered the primary cause of death due to infectiouscardiomyopathy. Historically, seropositive patients without discernible symptomsof cardiomyopathy have been grouped under the "indeterminate" classification.This categorization has perpetuated the lack of care of ~70% of CD patients. Bythe measurement of the carotid-femoral pulse wave velocity (cf-PWV), recentresearch has unveiled that indeterminate patients manifest increased aorticstiffness (IAS), the primary risk indicator of developing CVD. To contribute to thecurrent extent of knowledge of TC infection as a factor in triggering CVD andhemodynamic disorders, we have evaluated “residual” hemodynamic andmetabolic risk factors in infected mice and CD-patients, respectively.To study hemodynamic risk factors associated with vessel alterations, Balb/c micewere infected with TC (Tulahuen strain), and the cell populations of thoracic,abdominal, and brachiocephalic aortic segments were analyzed by FACS atdifferent days post-infection (dpi), using uninfected mice as controls. In the acutephase of infection (18 dpi), TC induced increased frequency (%) of CD45+ CD3+(p