INDUCTION OF HEMOXYGENASE 1 (HO1) PREVENTS ACUTE HEPATIC CHOLESTASIS PRODUCED BY OXIDATIVE STRESS (OS) IN THE RAT

MARTÍN, PAMELA LUCÍA; CECCATTO, PAULA; ARRIAGA SANDRA; SANCHEZ POZZI EJ; ROMA MG; BASIGLIO CL

Buenos Aires

Congreso; Reunión Conjunta de Sociedades Biomédicas; 2017

SAIC, SAFIS, SAH, SAB, SAB, SAFE, SAI, SAIB, SAP, SAA

Here, we studied the effect of HO1 induction and consequent increase in endogenous levels of bilirubin (BR) on OS-induced cholestasis. Wistar rats were treated with Hemin (H) and biliary concentrations of BR were determined, finding that it increased 6-8h post i. p. injection of 20 mg/kg H (12.6±2.5 vs 5.3±0.6 for vehicle, p