ASSOCIATION BETWEEN THE REGULATION OF GLYCEMIA AND PLASMA LEVELS OF VITAMIN D IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

LIOI, SUSANA; MASSONI, CLAUDIA; DE VUONO, DANIEL; PEREZ GOIRI, CAROLINA; PACUSSE, ALBERTO; EVANGELISTA, RUBÉN; DANIELE, STELLA; PELUSA, HECTOR; BASIGLIO CL; ARRIAGA SANDRA

Congreso; XXI Congreso y XXXIX Reunión Anual Sociedad de Biología de Rosario; 2019

Sociedad de Biología de Rosario

Type 2 diabetes mellitus (T2DM) is a metabolic disease originated by a resistance to the action of insulin and a deficiency in its secretion. Worldwide, prevalence of T2DM has reached levels of pandemia in accordance with the increase in obesity. After de discovery of receptors of vitamin D in pancreatic and immune cells, its effects on different body functions have been investigated. It has been observed that individuals with insufficient levels of vitamin D are more predisposed to develop T2DM and that patients with vitamin D deficiency and intolerance to glucose have improved their metabolic status after vitamin supplementation. The aim of our work was to analyze the possible association between the serum levels of vitamin D and glycosylated hemoglobin (HbA1c) in subjects with T2DM. Having signed the informed consent, 19 samples of patients with DM, 13 of female gender and 6 of male gender, with ages ranging from 55 to 87 years old were processed. All patients were under treatment with oral hypoglucemiants drugs or insulin or a combination of both. Plasma levels of fasting glycemia (G, mg/dl), HbA1c (%), total cholesterol (C, mg/dl), HDL-cholesterol (HDL-C, mg/dl), and triglycerides (TG, mg/dl) were assessed by means of Cobas c311 autoanalyzer (Roche). Serum levels of 25-hydroxi-vitamin D (25-OH-D, ng/ml) were quantified by electrochimioluminiscence immunoassay. Patients were divided in 2 groups based on the levels of metabolic control of his/her glycemia: good control (GC, n=10) when HbA1c levels were < 7% and bad control (BC, n=9) when HbA1c levels were > or = 7%. Results for G, C, HDL-C, TG and 25-OH-D were as follows (mean±SD), for groups GC and BC, respectively: 119±33 vs. 150±33; 195±55 vs. 180±43; 54±11 vs. 53±11; 145±80 vs. 121±51 and 9.5±9.4 vs. 12±8. The TG/HDL-C index was also calculated as an indicator of insulin resistance and the obtained vaues were as follows (mean±SD): 8.9±0.7 for GC and 9.0±0.6 for BC. No significant differences were found for any of the parameters studied between both groups (p>0.05) except for G (p