Anti-inflammatory properties of two new copper(II) complexes with Fenoprofen

MARIELA A. AGOTEGARAY; MÓNICA A. BOERIS; OSCAR V. QUINZANI

Córdoba

Congreso; 1st Annual RICiFA Meeting (International Meeting on Pharmaceutical Sciences 2010); 2010

The proposed curative properties of copper based non-steroidal anti-inflammatory drugs (NSAIDs) have led to the development of copper(II) complexes of NSAIDs with enhanced anti-inflammatory activity and reduced gastrointestinal toxicity compared with their uncomplexed parent drugs. No copper(II) anti-inflammatory drug is currently available for oral human use, although a gel base of copper-salicylate (Alcusal®) is available for topical temporal relief of pain an inflammation in humans in Australia. Copper is an essential trace element, taking part in all aspects of metabolism. It is believed to possess anti-inflammatory activity and has been proposed an increased demand for copper during inflammatory conditions.             Fenoprofen, 2-(3-phenoxyphenyl)propionic acid, is an  antipyretic, analgesic and NSAID. Little is known about chemical structures of Fenoprofen complexes and copper drugs have yet to reach an extended human market, so in this work we present the enhanced anti-inflammatory activity of two new copper(II) complexes with Fenoprofen.