Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal and SOD-mimic activity studies

MARIELA A. AGOTEGARAY (CORRESPONDING AUTHOR); MÓNICA A. BOERIS; ALEJANDRA S. DIEZ; MARÍA R. PRAT; OSCAR V. QUINZANI

JOURNAL OF COORDINATION CHEMISTRY

TAYLOR & FRANCIS LTD

Año: 2011 vol. 64 p. 2246 - 2261

0095-8972

Three dinuclear copper(II) complexes with the anti-inflammatory drug Fenoprofen [Hfen, 2-(3-phenoxyphenyl)propionic acid] and nitrogen donors of general formula [Cu2(fen)4(L)]n were prepared from [Cu2(fen)4(dmf)2].2H2O (1) [dmf=N,N´-dimethylformamide; L=4,4´-bipyridine(2), pyrazine (3), and 2,5-dimethylpyrazine (4)]. The new complexes were characterized by chemical analysis, spectroscopic, and thermogravimetric techniques. Antioxidant properties of1?4 were evaluated for superoxide-dismutase-mimic activity employing the XTT method.Complex 2 presented the highest antioxidant activity (IC50=0.260 mmol L1). Anti-inflammatory properties of 2 were evaluated employing carrageenan-induced paw edema in mice, revealing that the Fenoprofen?copper(II) complex containing 4,40-bipyridine does not present enhanced anti-inflammatory activity compared to the uncomplexed parent drug Fenoprofen calcium salt.