INVESTIGADORES
MELANI Mariana
artículos
Título:
Robustness of the hypoxic response: another job for miRNAs?
Autor/es:
ANA L. DE LELLA EZCURRA; AGUSTINA P. BERTOLIN; MARIANA MELANI; PABLO WAPPNER
Revista:
DEVELOPMENTAL DYNAMICS
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2012 p. 1842 - 1848
ISSN:
1058-8388
Resumen:
Living organisms are constantly exposed to environmental and genetic
perturbations. Biological robustness enables these organisms to maintain
their functional stability in the presence of external or internal
changes. It has been proposed that microRNAs (miRNAs), small non-coding
regulatory RNAs, contribute to robustness of gene regulatory networks.
The hypoxic response is a major and well-characterized example of a
cellular and systemic response to environmental stress that needs to be
robust. miRNAs regulate the response to hypoxia, both at the level of
the main transcription factor that mediates this response, the
hypoxia-inducible factor (HIF), and at the level of one of the most
important systemic outcomes of the response: angiogenesis. In this
review, we will take the hypoxic response as a paradigm of miRNAs
participating in circuits that provide robustness to biological
responses.