INVESTIGADORES
MOURIÑO Viviana Silvia Lourdes
artículos
Título:
Single-step electrochemical deposition of antimicrobial orthopeaedic coatings based on bioactive glass/chitosan/nano-silver composite system
Autor/es:
F. PISHBIN; V. MOURIÑO; J. GILCHRIST; MCCOMB D; S. KREPPEL; V. SALIH; M. RYAN; A. R. BOCCACCINI
Revista:
ACTA BIOMATERIALIA
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 9 p. 7469 - 7479
ISSN:
1742-7061
Resumen:
Composite orthopaedic coatings with antibacterial capability containing chitosan, Bioglass® particles (9.8ìm) and silver nanoparticles (Ag-np) were fabricated using a single-step electrophoretic deposition (EPD) technique, and their structural and preliminary in vitro bactericidal and cellular properties were investigated. Stainless steel 316 was used as a standard metallic orthopaedic substrate. The coatings were compared with EPD coatings of chitosan and chitosan/Bioglass®. The ability of chitosan as both a complexing and stabilizing agent was utilized to form uniformly deposited Ag-np. Due to the presence of Bioglass® particles, the coatings were bioactive in terms of forming carbonated hydroxyapatite in simulated body fluid (SBF). Less than 7wt.% of the incorporated silver was released over the course of 28days in SBF and the possibility of manipulating the release rate by varying the deposition order of coating layers was shown. The low released concentration of Ag ions (
