INVESTIGADORES
MOURIÑO Viviana Silvia Lourdes
artículos
Título:
Preparation and characterisation of gallium releasing 3-D alginate coated 45S5 Bioglass® based scaffolds for bone tissue engineering
Autor/es:
V MOURIÑO, P. NEWBY, A. R. BOCCACCINI
Revista:
Adv. Eng. Mater. Journal
Editorial:
John Wiley & Sons, Inc.
Referencias:
Lugar: Londres; Año: 2010 vol. 12 p. 283 - 291
ISSN:
1438-1656
Resumen:
The aim of this work was to develop functional three-dimensional scaffolds based on Bioglass® derived glassceramics for bone tissue engineering (TE) with prophylaxis effect against infections. The highly porous scaffolds were fabricated by the foam replication technique and then coated with sodium alginate crosslinked with Ga3+. It was confirmed that the polymer coating did not affect the interconnectivity of the scaffold pore structure. The resulting composite scaffold exhibited antibacterial effect and improved mechanical properties as well as high bioactivity. The novel Ga3+ loaded 45S5 Bioglass-based scaffolds coated with alginate are promising candidates for bone TE applications.
