Veterinary Guidelines for Electrochemotherapy of superficial tumors

MAGLIETTI FELIPE; MIR, LLUIS M.; TELLADO MATIAS

Copenhagen

Congreso; The 4 World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, and Food & Environmental Technologies,; 2022

International Society for Electroporation based Technologies and Treatments

Electrochemotherapy (ECT) consists in the application of electric pulses to increase chemotherapeutic drug intake(bleomycin, cisplatin, or calcium) into the tumor cells. It has become a very valuable treatment option in veterinary oncology.It is an effective and safe treatment modality, which is not only beneficial as a palliative treatment, but also for a curativeapproach. Performing the treatment adequately will ensure the best results possible, in the minimum number of sessions, and reduce complications. Usually, only one session is enough to achieve excellent results, but the treatment can berepeated. Several sessions can be necessary in the case of incompletely treated or very extended lesions, as well as in theoccurrence of new lesions. ECT is effective for superficial or oral tumors of any histology that are accessible to theelectrodes. Intravenous bleomycin is the preferred drug and route of administration, leaving other ways of administrationand drugs for selected cases. The guidelines presented here are destined to veterinarians who want to develop theirunderstanding of the basis of ECT and wish to perform it adequately and effectively. In this paper, we also discuss commonproblems and how to solve them, and we include practical tips to improve the treatment results based on commonquestions and mistakes of beginner users.