Heme Oxigenase-1 decreases the invasive phenotype in breast cancer.

CURINO, A.C.; FERRONATO, M.J.; ALONSO, E.N.; FERMENTO, M.E.; OBIOL, D. J.; FACCHINETTI, M.M.; GANDINI, N.A.

Bariloche

Simposio; III South American Symposium in Signal Transduction and Molecular Medicine (SISTAM); 2015

Cell invasion involves changes in cell-cell and cell-extracellular matrix interactions. E-cadherin (E-cadh) and Beta-catenin (Beta-cat) participate as anchor proteins of epithelial cell-cell interactions and have been shown to be deregulated in breast cancer (BC). Previous results from our laboratory demonstrated a role of heme oxygenase 1 (HO-1) in the progression of BC, although the mechanism of action has not yet been addressed. Therefore, the aim of this work was to assess if HO-1 has a role in breast cancer metastasis and for this purpose we have begun studying HO-1 effects on cell migration and invasion and on E-cadh and Beta-cat levels.The results obtained in human BC biopsies demonstrate that there is a positive correlation between the expression of HO-1 and E-cadh (p = 0.0144; Spearman test), as detected by immunohistochemistry (IHC). In the murine LM3 BC cells, pharmacological activation of HO-1 with hemin increased expression of E-cadh and Beta-cat (p