INVESTIGADORES
CROCI RUSSO Diego Omar
artículos
Título:
DELINEATING THE INTRACELLULAR SIGNALING PATHWAYS TRIGGERED BY GALECTIN-GLYCAN INTERACTIONS
Autor/es:
DIEGO J. LADERACH; DANIEL COMPAGNO; MARTA A. TOSCANO; DIEGO O. CROCI; SEBASTIÁN DERGAN-DYLON; MARIANA SALATINO; GABRIEL A. RABINOVICH
Revista:
IUBMB LIFE
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: Londres; Año: 2010 vol. 62 p. 1 - 13
ISSN:
1521-6543
Resumen:
Galectins are a family of evolutionarily conserved animallectins with pleiotropic functions and widespread distribution.Fifteen members have been identified in a wide variety of cellsand tissues. Through recognition of cell surface glycoproteinsand glycolipids, these endogenous lectins can trigger a cascadeof intracellular signaling pathways capable of modulating celldifferentiation, proliferation, survival, and migration. Thesecellular events are critical in a variety of biological processesincluding embryogenesis, angiogenesis, neurogenesis, andimmunity and are substantially altered during tumorigenesis,neurodegeneration, and inflammation. In addition, galectins canmodulate intracellular functions and this effect involves directinteractions with distinct signaling pathways. In this review, wediscuss current knowledge on the intracellular signaling pathwaystriggered by this multifunctional family of b-galactosidebindingproteins in selected physiological and pathologicalsettings. Understanding the galectin signalosome will be essentialto delineate rational therapeutic strategies based on the specificcontrol of galectin expression and function.
