NURSE-LIKE CELLS CONTROL THE ACTIVITY OF CHRONIC LYMPHOCYTIC LEUKEMIA B CELLS VIA GALECTIN-1

CROCI DO; P. MORANDE; DERGAN DYLON S.; M. BORGE,; M. A. TOSCANO; STUPIRSKI JC; R. F. BEZARES; AVALOS JS; M. NARBAITZ; CAMBERALE R; GA. RABINOVICH; M. GIORDANO

LEUKEMIA

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2013 p. 1413 - 1416

0887-6924

Chronic lymphocytic leukemia (CLL) cells are preferentially activated in so-called proliferation centers frequently found in lymph nodes and bone marrow from CLL patients.1 In these ?privileged? sites leukemic cells establish close contact with a variety of cell types that provide long-term support for their survival and progression. In addition, CLL cells favor the establishment of immunosuppressive microenvironments by altering the cytokine milieu.2 Galectin 1 (Gal1), an endogenous b-galactoside-binding lectin found at sites of inflammation and tumor growth, displays pro-survival activity on malignant cells as demonstrated for CD45RA( 􏰀 ) primary myeloma cells.3