INVESTIGADORES
CROCI RUSSO Diego Omar
artículos
Título:
Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications
Autor/es:
MASCANFRONI ID; CERLIANI JP; DERGAN-DYLON S; CROCI DO; ILARREGUI JM; RABINOVICH GA
Revista:
INTERNATIONAL IMMUNOPHARMACOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsternam; Año: 2011 p. 833 - 841
ISSN:
1567-5769
Resumen:
In spite of their central role in orchestrating immunity, dendritic cells (DCs) can also limit harmful reactions
and promote immune tolerance by inducing T cell anergy or favoring the differentiation of T regulatory (Treg)
cells. Several factors may influence the decision of DCs to become immunogenic or tolerogenic including the
nature of antigenic challenge, the engagement of selective pathogen recognition receptors (PRRs) and the
balance of cytokines and growth factors. In addition, mounting evidence indicates a key role of endogenous
lectins including C-type lectins, siglecs and galectins in shaping DC immunogenicity and tailoring adaptive
immune responses, through recognition of specific glycan signatures on invading pathogens or host cells.
While galectins are in general secreted proteins that act in a paracrine or autocrine manner, all known siglecs
and most C-type lectins are membrane-bound receptors that convey glycan-containing information into DC
differentiation or maturation programs. Yet, some of the signaling pathways triggered by endogenous lectins
converge in similar functional outcomes regardless of divergences in their structure, homology or glycan-
binding specificity. To gain a more complete understanding on the role of proteinglycan interactions in DC
biology, here we will integrate scattered information on these structurally-divergent but functionally-related
lectins and their potential biomedical applications.