INVESTIGADORES
BOHL Luciana Paola
artículos
Título:
PAROTID SIALOSIS: MORPHOMETRICAL ANALYSIS OF THE GLANDULAR PARENCHYME AND STROMA AMONG DIABETIC AND ALCOHOLIC PATIENTS
Autor/es:
CAROLINA MERLO, LUCIANA BOHL, CARMEN CARDA, MARÍA ELSA GÓMEZ DE FERRARIS, MIRIAM CARRANZA
Revista:
JOURNAL OF ORAL PATHOLOGY AND MEDICINE
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2010 vol. 39 p. 10 - 15
ISSN:
0904-2512
Resumen:
BACKGROUND: Among the agents that cause parotid
sialosis, diabetes mellitus type 2 and chronic alcoholism
are included. In this study, the morphometrical modifications
in the diabetic parotid sialosis were determined
to compare them with the histopathological characteristics
of alcoholic parotid sialosis.
METHODS: Five parotid biopsy samples obtained from
patients with diabetic sialosis, 12 samples from patients
with alcoholic sialosis and seven from individuals without
these pathologies (control group) were analyzed. A
morphometrical study of parotid parenchyme and stroma,
using a digital image analyzer attached to an optical
microscope, was carried out. Dimensions of serous acini
and striated ducts, the area occupied by the fatty tissue,
and the number of ducts were recorded. Mean values
were compared using the MannWhitney U-test
(P £ 0.05).
RESULTS: The variables analyzed in diabetic patients did
not show significant differences with respect to the control
group. However, when diabetics were compared with
alcoholics, the alcoholics exhibited a noticeable reduction
in the proportion of fatty tissue of stroma and a significant
development of ductal epithelium that contributed
to increase the caliber of the striated ducts.
CONCLUSIONS: These results indicate that the glandular
hypertrophy in the diabetic parotid sialosis is not
directly associated with the ductal and acinar size,
amount of fatty tissue and ductal hyperplasy. Nevertheless,
these findings show that the ductal dimensions and
the proportion of adipose tissue are variables that allow
us to establish histopathological differences between
diabetic and alcoholic sialosis.
J Oral Pathol Med (2010) 39: 1015