MOLECULAR ASPECTS OF VITAMIN D ANTICANCER ACTIVITY

PICOTTO G; LIAUDAT AC; BOHL L; TOLOSA DE TALAMONI N

CANCER INVESTIGATION

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2012 p. 604 - 614

0735-7907

Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical and genetic studies have shown non classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis and alters cellular adhesion, the precise mechanisms of its action are still not completely established. This article will present a revision about the molecular aspects proposed to be involved in the anticancer action of calcitriol. Adequate levels of vitamin D to prevent cancer development will be also discussed.