INVESTIGADORES
LOCATELLI Fernando Federico
congresos y reuniones científicas
Título:
Interaction among appetitive and aversive pathways during learning and memory formation in honey bees
Autor/es:
KLAPPEBACH MARTIN; LOCATELLI FERNANDO
Lugar:
Huerta Grande, Cordoba
Reunión:
Congreso; Congreso SAN 2013; 2013
Institución organizadora:
Sociedad Argentina de Investigaciones en Neurociencias
Resumen:
Interaction
among appetitive and aversive pathways during learning and memory formation in
honey bees
Martin Klappenbach and Fernando
Locatelli
Laboratorio de Neurobiología de la Memoria. FCEN-UBA. IFIBYNE-CONICET
How
appetitive and aversive stimuli are encoded in the brain to induce learning and
memory is a relevant question in neuroscience: Insect are useful models to
tackle this issue since both kinds of stimuli can be delivered in a discrete way
while animals are restrained and prepared for neural recordings. Networks and
neurotransmitters involved in appetitive and aversive pathways have started to
be revealed. In honey bees and other insects, it was demonstrated that
octopamine mediates the appetitive stimulus necessary for appetitive learning, while
serotonine and dopamine (DA) mediate the aversive stimuli. In this work we postulate
that pure appetitive or aversive experiences do not exist in nature and that
action of appetitive and aversive pathways must work coordinated to ensure
adaptive behavior. Accordingly we found DA, so far only involved in aversive learning
in bees, interferes with the appetitive memory formation and that administration
of a DA receptor antagonist produces an enhancement in appetitive memory,
revealing the tonic modulation of this amine over the appetitive signaling. It
is not known yet at what level from sensory processing to control of motor
output this interaction take place. We postulate that this negative modulation
is due a downregulation of the sucrose induced signal. This has motivated us to study, by calcium
imaging, how DA modulates neural signals in response to sugar and odors at
different levels of stimuli processing. As a first step, we observe that DA
increases the signal evoked by odor in the antennal lobe (AL), the first relay
in the odors' processing. This could allow animals to enhance perception of an
aversive paired odor. In the same way, we hypothesis that DA should decrease
the signal evoked by sucrose, providing a neural substrate for the interference
observed in the appetitive memory formation.