k-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

FREUDENTHAL R; LOCATELLI F; HERMITTE G; MALDONADO H; LAFOURCADE C; ROMANO A

NEUROSCIENCE LETTERS

Elsevier

Lugar: New Haven, CT, USA.; Año: 1998 vol. 242 p. 146 - 146

0304-3940

Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NFk-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/k-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/k-B like DNA-binding activity in the brain is specifically related to LTH formation.