Chronic prostate inflammation as a risk factor for prostate cancer development. Study of an animal model

SALAZAR, FLORENCIA C.; GODOY, GLORIA J.; PAIRA, DANIELA A.; OLIVERA, CAROLINA; RIVERO, VIRGINIA E.; MOTRICH, RUBEN D.

Mar del Plata

Congreso; LXVI Reunión Anual de SAI, LXIII Reunión Anual de la SAIC, Reunión Anual de la SAFIS, IX Reunión Anual de la NANOMEDAR, Reunión Anual de la SAV; 2018

Prostate cancer (CaP) is the second most common type of cancer in men. It is a multifactorial disease and environmental and genetic factors are involved in his development. Epidemiological studies have suggested chronic inflammation as a major risk factor. Herein, we analyzed if chronic inflammation may have a role in prostate carcinogenesis using an animal model of chronic bacterial prostatitis.C57BL/6 male mice were transurethrally inoculated with 2x108 CFU of uropathogenic E. coli 1677 (infected) or saline (controls), euthanized at 5 days (dpi), 12 or 26 weeks (wpi) post infection, and prostate infiltrating leukocytes, histopathology and immunohistochemistry/immunofluorescence for different PCa associated lesions were performed/analyzed.Infected mice developed an acute prostate infection (5 dpi) that evolved chronic (12 and 26 wpi). Infection induced prostate inflammation. Higher counts of tissue infiltrating CD45+ leukocytes were detected at 5 dpi (p