INVESTIGADORES
KATZ Eleonora
artículos
Título:
The efferent medial olivocochlear-hair cell synapse
Autor/es:
ANA BELÉN ELGOYHEN; ELEONORA KATZ
Revista:
JOURNAL OF PHYSIOLOGY (PARIS)
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2011
ISSN:
0928-4257
Resumen:
Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels 23back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts 24with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated 25by a unique nicotinic cholinergic receptor composed of a9 and a10 subunits, which is highly Ca2+ perme- 26able and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows 27efferent fiber activation. In this work we review the literature that has enlightened our knowledge con- 28cerning the intimacies of this synapse.
