INVESTIGADORES
GONZALEZ DENISELLE Maria Claudia
artículos
Título:
Dexamethasone up-regulates mRNA for neuronal Na,K-ATPase in spinal cord after transection
Autor/es:
GONZÁLEZ S.L; GRILLO C; GONZÁLEZ DENISELLE, M.C.; LIMA ANALÍA; MC EWEN BS; DE NICOLA A. F.
Revista:
NEUROREPORT
Editorial:
LIPPINCOTT WILLIAMS & WILKINS
Referencias:
Lugar: Philadelphia; Año: 1996 vol. 7 p. 1041 - 1044
ISSN:
0959-4965
Resumen:
We have studied the effect of of spinal cord transection and of dexamethasone treatment on mRNA biosynthesis of the Na, K ATPase, a key enzyme necessary for neurotransmission, membrane repolarization and nutrient uptake in the CNS. In situ hybridization analysis revealed a significant reduction in mRNA for alpha3 catalytic subunit of the enzyme in medium and large size ventral horn neurons, but not in small cells 24h after spinal cord transection. DEX treatment significantly reversed the transection effect in medium and large size neurones. It is suggested that up-regulation of mRNA expression for hte Na, K ATPase may constitute an important mechanism by which glucocorticoids help to re-establish neuronal function after spinal cord injury.
