Long-chain acyl-CoA synthetase isoforms and their functions

COLEMAN, R.A.; VAN HORN, C.G.; GONZALEZ-BARO, M.R.; LEWIN, T.M.

Lipids: Glycerolipid Metabolizing Enzymes

Research Signpost

Lugar: Trivandrum, India; Año: 2002; p. 1 - 15

Five members of a family of long-chain acyl-CoA synthetases have been cloned and characterized. Their tissue distribution, subcellular locations, fatty acid preference and transcriptional regulation strongly suggest that each isoform plays an independent role in providing acyl-CoA substrates for specific pathways of complex lipid synthesis and of fatty acid oxidation. Much work remains to be done to identify the specific roles and regulation of these acyl-CoA synthetases