Magnetic hybrid nanomaterial based on a natural polymer and an Amino Acid as pH/temperature dual-responsive nanoplatform for delivery of tamoxifen

JAZMÍN TORRES; DIEGO CADENA CASTRO; ROSARIO ANCARANI; IGNACIO BRUVERA; PEDRO ZELIS; SANDRA E. MARTÍN; MÓNICA C. GARCÍA; PAULA M. UBERMAN

Frontiers in Nanotechnology

Frontiers, Frontiers Media SA

Año: 2024 vol. 6

2673-3013

This manuscript presents novel insights related to the synthesis and characterization of a stimuli-responsive hybrid magnetic nanoplatform (HMNP) for the triggered delivery of tamoxifen (TMX), intended to improve breast cancer therapy. We described the preparation of HMNP obtained by conjugating Fe3O4 nanoparticles with L-cysteine (L-Cys) and hyaluronic acid (HA). These modifiers improve aqueous dispersibility and, HA serves as a cell-specific targeting ligand. We fully characterize the nanomaterial physicochemically, its colloidal stability, and its interaction with plasma proteins. The HMNP exhibited small size, high stability, and efficient TMX loading (75%). Although we observed efficient control over TMX release toward different receptor media, drug release from HMNP-TMX was triggered at acidic pH and hyperthermia conditions, demonstrating its responsiveness to both stimuli. We also observed enhanced anticancer activity of TMX against MDA-MB-231 breast cancer cells when loaded into HMNP, suggesting improved cell uptake of TMX-loaded HMNP in this triple negative breast cancer cells. Our results indicate that HMNP-TMX shows promising properties as a stimuli-responsive nanoplatform for cancer nanomedicine, with prospects for magnetic hyperthermia therapy. We consider that our results will appeal to readers of Frontiers in Nanotechnology interested in improving the efficacy and safety of anticancer drugs in cancer nanomedicine.