INVESTIGADORES
PELAEZ Walter Jose
congresos y reuniones científicas
Título:
CONFORMATIONAL ANALYSIS OF CIS-TETRAHYDROQUINAZOLIN-4-ONES BY LOW TEMPERATURE NMR
Autor/es:
WALTER J. PELÁEZ; GUILLERMO M. CHANS; FERENC FÜLÖP; GUSTAVO A. ARGÜELLO
Lugar:
Riviera Maya, México
Reunión:
Conferencia; 11a Conferencia Latinoamericana de Físico-Química Orgánica (CLAFQO); 2011
Institución organizadora:
11a Conferencia Latinoamericana de Físico-Química Orgánica (CLAFQO)
Resumen:
In recent years, quinazolinones and their partially saturated analogs have come into the focus of interest because of their noteworthy pharmacological activity, e.g. nucleoside analogs with potential analgesic and antiinflammatory effects or thymidylate synthase inhibitor activity.1,2 Quinazolinones present tautomerism;3,4 therefore, the understanding of their equilibrium properties and energetics is relevant for the study of molecular processes leading to their pharmacological activities. Besides the existence of tautomers, there are other important structural features, especially for cis-quinazolinones, as for instance the coexistence of two distinct conformers (N-in and N-out)
