Glycemic index and glycemic load are associated with breast cancer risk in rural and urban contexts: a mulĕlevel analysis?

NICLIS, C; TUMAS, N; MUÑOZ, SE; DÍAZ, MP

Miami

Congreso; Epidemiology congress of the Americas; 2016

International epidemiology Association

The dietary glycemic index (GI) and glycemic load (GL) would increase the risk of diverse cancers, including breast cancer (BC). Factors other than individual exposures, such as contexts of residence, may be considered as determinants of this risk1. OBJECTIVESTo evaluate the association of dietary GI and GL with the risk in BC occurrence of adult women, assessing the urban?rural context dependency in Córdoba province in 2008-2015 period.a case control study for breast cancer has been conducted in Cordoba between 2008 ? 2014 Dietary exposure information has been collected using a Food Frequency Questionnaire and a photographical atlas based on standard food portion sizes3. Multilevel logistic regression models were fitted including:GI or GL, age, BMI, intake of energy and long chain fatty acids, age at menarche, number of children and age at first child, at the individual level.Level of urbanization (200,000 inhabitants), for the clustering level. disease status (presence/absence of BC) for the outcome.GI showed an increasing promoting effect for BC occurrence, instead, GL showed no association. A significant aggregation linked to the level of urbanization was observed, which explains above 15% of outcome variability, and improves the risk estimations Our results suggest that a diet with high GI is associated with an increased risk of BC, with differences related to the urban-rural contexts of residence.