THE ONSET OF THE WOMAN’S FERTILITY WINDOW: IN SEARCH OF ACCURATE BIOMARKERS.

KERZ, GUILLERMO; PAUL, INGRID; ZERBINI, ELSA; PERALTA, M. B.; VELÁZQUEZ, MML

Mar del Plata

Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIAS 2022; 2022

The identification of precise biomarkers and cut-off values to determine the onset of the woman’s fertility window has been subject of several research in reproductive physiology. However, little is known about precise parameters that contribute to an upgrade in women’s reproductive health. The aim of this study was to evaluate some markers during the menstrual cycle in women fertile age, at the beginning of the fertility window. The number of volunteer women that met the inclusion criteria was 44. The measurement of endometrial thickness and ovarian follicular diameter was evaluated by ultrasound from each volunteer. At the same time, blood samples to the evaluation of serum estradiol concentration by biochemistry and cervical mucus by microscopic analysis, were obtained. The ROC curves were used to analyze the results. The onset of the fertile phase was identified when the cervical mucus turned from infertile into fertile by microscopic observations. The serum estradiol concentration at the beginning of the fertile phase was 113 pg/ml, whereas the ovarian follicle diameter and the endometrial thickness were 15 mm and 7.5 mm, respectively, all of them chosen through Youden’s index. On the other hand, the area under the curve for serum estradiol was 0.772, for the follicular diameter was 0.794, whereas that for the endometrial thickness was 0.744 (CI 95%). These findings suggest the importance of identifying accurate biomarkers of the fertile period in women, which could be useful and good predictors for certain purposes. Furthermore, these results add information to a histoarchitecture of biomarkers aimed at improving accuracy in fertility management.