INVESTIGADORES
BOLMARO Raul Eduardo
artículos
Título:
Preparation, Characterization and Dissolution Studies of Fast Release Diclofenac Sodium Tablets from PVP Solid Dispersions
Autor/es:
MARÍA C. LAMAS; DARÍO LEONARDI; OSVALDO LAMBRI; GEORGINA BASSANI; MARÍA G. BARRERA; RAÚL E. BOLMARO; CLAUDIO J. SALOMÓN
Revista:
Pharmaceutical Development and Technology
Editorial:
Informa Farma Science
Referencias:
Año: 2009 p. 1 - 28
Resumen:
Diclofenac sodium is a non steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium- PVP K-30 fast release tablets from solid dispersions. The physical state and drug: carrier interactions were analysed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.
