AP control algorithms: a switched control approach for bihormonal glycemic regulation

EMILIA FUSHIMI; HERNÁN DE BATTISTA; FABRICIO GARELLI

Conferencia; 14th International Conference on Advanced Technology & Treatments for Diabetes.; 2021

Background and AimsSingle-hormone AP systems have shown to improve glucose regulation in people with T1D. However, a dual-hormone AP that relies in both insulin and glucagon for glycemic control is a promising therapy.MethodIn this work, a switched, dual-hormone controller is presented (ARGDH). This method extends the previously introduced Automatic Regulation of Glucose (ARG) algorithm [1], which has a switched LQG as its main insulin controller, to dual-hormone by means of adding a PD controller for glucagon dosing. Several criteria for the activation of the glucagon controller are considered, analyzing their effects on the AP system performance and safety.ResultsThe in silico study carried out in this work demonstrated that extending the ARG algorithm to a dual-hormone algorithm is feasible. The ARGDH proved that, with a proper selection of the activation criterion of the glucagon controller, it effectively avoids hypoglycemia episodes without increasing hyperglycemia nor the total amount of insulin infused a day.ConclusionSimulations show that the proposed dual-hormone ARG improves the performance of the single-hormone ARG algorithm.