METABOLIC AND IMMUNOENDOCRINE PROFILE IN SUBJECTS WITH CHRONIC CHAGAS DISEASE

GONZALES, FLORENCIA; VILLAR, SILVINA; LEIVA, RODOLFO; LIOI, SUSANA; MARQUEZ, JULIA; SCALGIONE, LORENA; BELOSCAR, JUAN; BOTTASSO, OSCAR; PEREZ, ANA ROSA

Buenos Aires

Congreso; IV LASI Meeting, LVIII Argentininean Immunology Society Meeting and II French-Argentine Immunology Meeting; 2015

The metabolic status of an individual is influenced by endocrine and immunologicalfactors. Chronic Chagas disease (ChC) is an infectious illness caused by the parasite Trypanosomacruzi, which could result in cardiomyopathy, a marked proinflammatory profile and a dysbalance in theDHEA/cortisol ratio. Recently, adipose tissue has been identified as target of T. cruzi infection, possiblyinfluencing the energetic metabolism and the severity of disease. The aim of this study was toinvestigate whether the levels of circulating factors involved in the inmunoendocrine and metabolicresponse in ChC patients are related to the severity of heart disease. For this, 109 patients and 24healthy individuals (Co) were recruited. ChC subjects were evaluated by ECG thoracic X-ray Rx andclassified as: Asymptomatic (without heart disease, Asy, n =46) or with cardiomyopathy (c/C, n =63),and subclassified as mild/moderate (LM, n = 31) or severe (Sev, n =32). Serum adiponectin, leptin, IL-6,insulin, body mass index (BMI) were evaluated. The data obtained showed that Sev had increased BMIand IL-6 compared to Co (p <0.05 in both cases). Leptin levels in Asy and c/C were higher than Co(p<0.01 and p<0.05 respectively], but in Sev were lower than LM (p<= 0.01). In ChC subjects leptinpositively correlated with BMI, IL-6 and insulin (p<0.05, all cases). In whole population adiponectinnegatively correlated with BMI (p <0.007) and was increased in Sev compared to Asy (p<0,05). Ourresults suggest that inflammatory and metabolic mechanisms may be related degree of cardiac severity.