Microbial transformation of S-(-)-Perillyl Alcohol by the filamentous fungi Fusarium verticillioides

SOLEDAD RAVETTI; ROXANA ACIAR; JORGE ALLENDES; MELISA ROSA; LISANDRO HERGERT; PAMELA BUSTOS; MARÍA GABRIELA ORTEGA; MARÍA GABRIELA PARAJE; DANIEL BUSTOS

Biotechnology: An Indian Journal

Trade Science Inc

Año: 2013 vol. 7 p. 1 - 5

0974-7435

S-(-)-Perillyl alcohol (1) was transformed by Fusarium verticilloides over 7 days at 25°C to S-(-)-Perillyl aldehyde (2). Its structure was establishedFusarium verticilloides over 7 days at 25°C to S-(-)-Perillyl aldehyde (2). Its structure was established°C to S-(-)-Perillyl aldehyde (2). Its structure was established by NMR spectroscopic and mass spectral studies. Total antioxidant potential and the radical-scavenging activity were determined by phosphomolybdenum and ABTS.+ assays, respectively. The results.+ assays, respectively. The results demonstrated that the oxidation of the primary alcohol of 1 had no effect on antioxidant activitywhen compared to startingmaterial and a reference compound. Obtaining derivatives of 1, is an important goal of research in microbial biotechnology and medicinal chemistry.