LIPOPHILICITY OF NOVEL 5’-CARBONATES OF LAMIVUDINE WITH ANTIRRETROVIRAL ACTIVITY. CORRELATION BETWEEN DIFFERENT METHODS

SOLEDAD RAVETTI, MARÍA S. GUALDESI, MARGARITA C. BRIÑÓN.

JOURNAL OF LIQUID CHROMATOGRAPHY AND RELATED TECHNOLOGIES

Marcel Dekker. INC

Lugar: New York; Año: 2008 vol. 31 p. 1014 - 1032

1082-6076

This study reports on the lipophilicity of novel 5’-carbonates of lamivudine with anti-HIV activity. Reversed-phase thin layer chromatography (RP-TLC), reversed-phase high performance liquid chromatography (RP-HPLC), conventional shake-flask (log Poct), and the theoretical CLOGP methods were used, in order to establish if the linear relationships between the conventional and chromatographic methods permit an extrapolation procedure. The nature of the organic modifiers used in the chromatographic techniques did not substantially affect the measurement of lipophilicity, since a good correlation between experimental log Poct and extrapolated RP-TLC and RP-HPLC values (RMw and log k’w, respectively) supported the validity of the extrapolation technique.