Resolvin D5 present in tuberculous pleural effusions promotes a pro-resolving profile in macrophages by impairing HIF-1α in response to Mycobacterium tuberculosis

JOAQUINA BARROS; MARIANO MAIO; JOSÉ L. MARIN FRANCO; FLORENCIA SABBIONE; FEDERICO FUENTES; DOMINGO PALMERO; XAVIER ARAGONE; RAFAEL J ARGÜELLO; EMILIE LAYRE; GEANNCARLO LUGO VILLARINO; OLIVIER NEYROLLES; AGUSTINA ERREA; CHRISTEL VÉROLLET; BALBOA LUCIANA

San Luis

Congreso; LXXI Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2023

Tuberculosis, caused by Mycobacterium tuberculosis, remains a major global health problem accounting for millions of deaths annually. Previously, we found that proinflammatory (M1) macrophages exposed to the acellular fraction of pleural effusions from TB patients (TB-PE) displayed a reduced glycolytic activity by targeting the hypoxia-inducible factor (HIF)-1α expression, and ultimately impairing the resistance to infection. Such properties were driven by polyunsaturated fatty acid metabolites within TB-PE fractions. In particular, we found that the abundances of 18-HEPE, 7(R)-Maresin 1, Protectin Dx and Resolvin D5 correlated with the inhibition of M1 macrophages’ glycolysis (p