THE GLYCOLYTIC STATUS OF MONOCYTES DURING TUBERCULOSIS LIMITS THE GLYCOLYSIS-POWERED MIGRATORY CAPACITY OF DENDRITIC CELLS IN RESPONSE TO MYCOBACTERIUM TUBERCULOSIS

MARIANO MAIO; MARINE JOLY; ZOI VAHLAS; JOAQUINA BARROS; JOSÉ LUIS MARÍN FRANCO; MELANIE GENOULA; FEDERICO FUENTES; MÓNICA VERMEULEN; RAFAEL J ARGÜELLO; SANDRA INWENTARZ; ROSA MUSELLA; LORENA CIALLELLA; PABLO GONZÁLEZ MONTANER; DOMINGO PALMERO; MARÍA DEL CARMEN SASIAIN; CHRISTEL VEROLLET; LUCIANA BALBOA

Congreso; LXX Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2022

Mycobacterium tuberculosis (Mtb) is a pathogen that interferes with dendritic cells (DCs) functions impairing the development of adaptive immunity. Herein we wondered how the metabolic pathways influence DCs activation in Tuberculosis (TB). We found that Mtb-stimulated DCs derived from monocytes of healthy donors displayed a predominant glycolytic profile, together with an increase in the expression of HIF1a and glycolytic genes (p