Chronic treatment with Zn-Telmisartan improves cardiac function and the protective renin-angiotensin-system axis in ovariectomized spontaneously hypertensive rats

MARTÍNEZ VR; DÍAZ RG; PÉREZ NG; VÉLEZ RUEDA JO; LOFEUDO JM; SILVA MG; GIRONACCI MM; WILLIAMS PAM; DE GIUSTI VC

Buenos Aires

Congreso; Reunión Científica 2021 de la Sociedad Argentina de Fisiología (SAFIS) en conjunto con la Asociación Latinoamericana de Ciencias Fisiológicas (ALACF),; 2021

Sociedad Argentina de Fisiología (SAFIS) en conjunto con la Asociación Latinoamericana de Ciencias Fisiológicas (ALACF)

During menopause, an imbalance between the pressor Angiotensin II (AngII) and the protective (Ang 1-7) arms of the renin-angiotensin systemp (RAS) exists, which leads to oxidative stress, hypertension and cardiac dysfunction. Restoring RAS balance would prevent cardiovascular diseases in menopausal women. We have previously modified the structure of the AngII receptor blocker telmisartan (Telm) with Zinc (ZnTelm), demonstrating higher drug effectiveness. In this work, we examined whether chronic ZnTelm treatment is a better alternative to prevent cardiovascular damage during menopause than Telm alone. We used 16-week-old spontaneously hypertensive rats (SHR) which were sham-operated or bilateral ovariectomized (OVX-SHR). OVX-SHR rats were randomly divided into 3 groups: non-treated (control), treated with Telm or ZnTelm (10 or 11 mg/kg/day, respectively, through drinking water for 8 weeks). Results (n=6 per group) were analyzed by ANOVA. * p