Na+/H+ exchanger and myocardial hypertrophy

CAMILIÓN DE HURTADO MC; PÉREZ NG; ENNIS IL; ÁLVAREZ BV; CINGOLANI HE

Signal Transduction and Cardiac Hypertrophy

Kluwer Academic Publishers

Lugar: Boston; Año: 2003; p. 125 - 135

Na+/H+ exchanger (NHE) is hyperactive in the hypertensive hypertrophied myocardium. Regression of cardiac hypertrophy (CH) induced by prolonged antihypertensive therapy with compounds of different pharmacological profiles (angiotensin converting enzyme inhibition, slow calcium channel and angiotensin II type 1 receptor blockade) normalizes the hyperactivity of myocardial NHE. Chronic treatment with selective NHE-1 inhibitors induced the regression of CH in SHR. Considered as a whole, these data support the notion of a causal link between the hyperactivity of the NHE-1 and the development of CH. Key words: Na+/H+ exchanger; cardiac hypertrophy; hypertension.