Radio-adaptive response in human lymphocytes

LIBKIND FRATI, DIEGO; BUNGE, M.M.; DURAND, J; GILLETE, V.H.

Radiobiología

Dpto. Radiología y Medicina Física. Univ. de Malaga, España.

Año: 2002 vol. 2 p. 38 - 43

1579-3087

The term radio-adaptive response (AR) applies to the phenomenon of protection or enhanced repair induced by a low radiation dose. Blood microcultures from 4 donors were irradiated to test the existence of AR in human lymphocytes using two different irradiation schemes. An adapting dose of 0.01 Gy and a challenging dose of 1.5 Gy of gamma radiation from a 2.5 MeV LINAC was used in all experiments. A cytogenetic analysis of unstable chromosome aberrations was applied as the endpoint. An inter-individual variability response was observed in one of the irradiation schemes: one donor expressed AR, two did not and the last showed an apparent synergistic response. The other irradiation scheme showed low mitotic indices (MI), suggesting a G2 arrest.