Adaptive response to ionizing radiation in Saccharomyces cerevisiae

DURAND, J.; VAN BROOCK, M.; LIBKIND FRATI, DIEGO; GILLETE, V.H.

Radiobiología

Dpto. Radiología y Medicina Física. Univ. de Malaga, España.

Año: 2002 vol. 2 p. 18 - 22

1579-3087

It is known that low doses of ionizing radiation called conditioning doses may induce resistance in exposed organisms to higher doses called challenging doses, and applied after a known period of time. Mechanisms involved in this phenomenon called Adaptive response are diverse and complex. The most important are the activation of DNA-repair enzymes and nuclear recombination processes. An aqueous suspension of the Baker´s yeast Saccharomyces cerevisiae type strain was used as "target". Adaptive response was verified by measuring the population survival in a wide range of challenging doses. Inductors of radio-resistance or conditioning doses were (0.44±0.03) Gy, and the lag time between them and the challenging doses was 2 hours at room temperature.