The pro- and anti-inflammatory balance and T-reg levels in patients with pulmonary tuberculosis treated with antimycobacterial drugs

DÍAZ, ARIANA; SANTUCCI, NATALIA; BONGIOVANNI, BETTINA; D'ATTILIO, LUCIANO; DÍDOLI, GRISELDA; BOGUE, CRISTINA; MARCHESINI, MARCELA; BOTTASSO, OSCAR; BAY, MARÍA LUISA

Lima

Congreso; X Congreso de la Asociación Latinoamericana de Inmunología ALAI 2012; 2012

At the time of diagnosis (T0), patients with Tuberculosis (TB) show a significantly increase of circulating pro-inflammatory mediators and Cortisol/DHEA ratio associated with disease severity. Hence, we have now analyzed the immune-endocrine parameters modifications during the anti-tuberculous treatment attempting to ascertain their utility as biomarkers. Blood samples were collected from 16 healthy controls (HCo) and 14 age- and sex-matched TB ?HIV negative- patients at T0 as well as at 2 (T2), 4 (T4) and 6 months (T6) of treatment initiation and 3 months post treatment. At T0, leucocytes were increased at the expense of neutrophils with a lymphocyte diminution (p