SHORT AND LONG-TIME EVALUATION OF THE ANTI-SARS HUMORAL RESPONSE IN VOLUNTEERS GIVEN ANTI-COVIS VACCINES

NAIDICH GRETEL; SANTUCCI NATALIA; CECCARELLI, EDUARDO; PEZZOTTO, STELLA; BOTTASSO, OSCAR; PERICHÓN, MARIO

MAR DEL PLATA

Congreso; Reunión de sociedades de Biociencias 2022; 2022

Anti-COVID vaccination showed some delays between the administration of the first and second doses along with a combination of different vaccine platforms. Considering the relevance of the antibody response in viral infections, we analyzed anti-S IgG, at different time points following Sputnik immunization, in healthy people attending the vaccination centers of Rosario city, who had shorter versus longer intervals between both doses. A total of 1035 adults with no COVID-compatible symptoms (throughout the study period) were separated according to the length between both vaccine doses: 21 (Group A, n=528), 30 (Group B, n=147), and 70 days (Group C, n=82), as well as an additional group of individuals with heterologous vaccination (Sputnik/Moderna, separated by a 107-day interval, n=278). While there were no between-group differences in baseline levels of specific antibodies, data at the time of administering the second dose showed that group D had the highest amounts of specific antibodies followed by values recorded in Groups C, A, and B (p