Meta-tyrosine inhibits the proliferation of established metastases in human adenocarcinoma and induces apoptosis in tumor cells without apparent toxic effects for the organism

ARIEL RAMIRO STRAZZA; DANIELA MONTAGNA,; ALCAIN JULIETA,; SEQUEIRA GONZALO; VERMEULEN, MÓNICA; RUGGIERO RAUL; CHIARELLA PAULA;

Congreso; Reunión Conjunta de Sociedades de Biociencia.; 2017

The development of new strategies to limit metastatic growth after tumor removal is one of the greatest clinical challenges today. In previous work we have shown that meta-tyrosine (m-tyr), an isomer of tyrosine absent in normal proteins, is responsible, at least in part, for the phenomenon of Concomitant Tumor Resistance (CR); in which a tumor-bearing host inhibits the growth of secondary tumor implants. In this work we propose a deeper understanding of the molecular and antitumor mechanisms involved in CR as well as the study of the effectivity of its administration by the intraperitoneal (i.p) route. NOD scid gamma mice with a 41-day MDA-MB-231 human tumor received a daily i.p injection of 2.5 mg/mouse of m-tyr or saline (control) for 18 days. After the treatment all mice were sacrificed and lung metastases counted. At day 59 the number of metastases (Median [range]) was 10.0 [4-39] and 4.0 [0-14] for the control and m-tyr group respectively (p