INVESTIGADORES
GOMEZ Cesar Gerardo
artículos
Título:
Synthesis and characterization of a beta-CD-alginate conjugate
Autor/es:
CESAR G. GOMEZ; GÉRARD CHAMBAT; ALAIN HEYRAUD; MARCELO VILLAR; RACHEL AUZÉLY-VELTY
Revista:
POLYMER
Editorial:
Elsevier
Referencias:
Año: 2006 vol. 47 p. 8509 - 8516
ISSN:
0032-3861
Resumen:
Selective chemical modification of both b-cyclodextrin (b-CD) and sodium alginate (alg) was performed in order to produce an alginate
derivative possessing pendant b-CD cavities along the chain. The latter was then fully characterized in terms of chemical integrity and purity,
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
derivative possessing pendant b-CD cavities along the chain. The latter was then fully characterized in terms of chemical integrity and purity,
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
derivative possessing pendant b-CD cavities along the chain. The latter was then fully characterized in terms of chemical integrity and purity,
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
b-cyclodextrin (b-CD) and sodium alginate (alg) was performed in order to produce an alginate
derivative possessing pendant b-CD cavities along the chain. The latter was then fully characterized in terms of chemical integrity and purity,
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
b-CD cavities along the chain. The latter was then fully characterized in terms of chemical integrity and purity,
complexation properties and ability to form hydrogels. Thus, a sodium alginate derivative modified with adipic dihydrazide (alg-ADH) and a
b-cyclodextrin derivative possessing an aldehyde function on the primary face were synthesized, and both were selectively coupled by a reductive
amination-type reaction. Comparison of the complexation properties of the grafted and natural b-CDs by isothermal titration calorimetry using
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
amination-type reaction. Comparison of the complexation properties of the grafted and natural b-CDs by isothermal titration calorimetry using
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
amination-type reaction. Comparison of the complexation properties of the grafted and natural b-CDs by isothermal titration calorimetry using
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
-cyclodextrin derivative possessing an aldehyde function on the primary face were synthesized, and both were selectively coupled by a reductive
amination-type reaction. Comparison of the complexation properties of the grafted and natural b-CDs by isothermal titration calorimetry using
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
b-CDs by isothermal titration calorimetry using
sodium adamantane acetate as a model guest gave similar enthalpy values suggesting similar mechanisms of binding. However, the association
constant for the grafted CD is slightly lower as a result of a less favorable change in the binding entropy. Investigation of the gelation ability in
the presence of calcium ions led to the following order: alg > alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
> alg-ADH > alg-CD. The decrease of gelation efficiency for the modified alginate
samples reflected the reduction of ionic interchain bonds as a result of the unavailability or non-accessibility of G units on the alginate backbone,
due to the chemical modification and steric effect of the CD molecule for alg-CD.
2006 Elsevier Ltd. All rights reserved.2006 Elsevier Ltd. All rights reserved.