Synthesis, characterization, and antibacterial activities of novel starch derivatives against E. coli and S. aureus

SOSA SANTILLÁN, GERARDO DE JESÚS; ZUGASTI CRUZ, ALEJANDRO; ENRÍQUEZ MEDRANO, FRANCISCO JAVIER; AVÉROUS, LUC; POLLET, ERIC; VALDÉS RAMOS, KARYME GUADALUPE; GOMEZ, CESAR GERARDO; ROMERO, MARCELO RICARDO; GARCIA LOBATO, MARCO ANTONIO; PÉREZ AGUILAR, NANCY VERÓNICA; OYERVIDES MUÑOZ, ERNESTO

STARCH/STARKE

WILEY-V C H VERLAG GMBH

Año: 2022 vol. 74 p. 2100142 - 2100142

0038-9056

Three novel starch derivatives with antibacterial properties are synthesizedthrough a rather simple multistep synthesis route. In a first step, sodium periodate oxidation of the hydroxyl groups (C2?C3) of starch yields a di-aldehyde structure, which is used to attach N,N-dimethylbenzylamine bySchiff base formation. Then, the amino groups of aminated starch are quaternized with three different ammonium salts (4-bromobutyl-pyridiniumbromide, 4-bromobutyl-benzalkonium bromide, and 4-bromobutyl-quinolinium bromide). The different resulting products are fully characterized by FTIR, 1H NMR, and SEC analysis. Their antibacterial properties are evaluated against Escherichia coli and Staphylococcus aureus in vitro to obtain minimum inhibitory and bactericidal concentrations. All the starch derivatives show strong antibacterial activities against Gram-negative E. coli strain and Gram-positive S. aureus. Finally, hemolysis assays show that two of the starch derivatives obtained have no significant hemolytic effect on isolated human red cells.