Levels of lymphocytes CD4 CXCR3, CD4 CCR6 and CD4 CCR4 in patients infected with human immunodeficiency virus HIV-1

PIERI EC; BRESER ML; LUNA N; DAVID D; RIVERO VE

Los Cocos

Congreso; LXI Reunión Científica de la Sociedad Argentina de Inmunología; 2013

Sociedad Argentina de Inmunologia

Infection with human immunodeficiency virus type 1 (HIV-1) is characterized by a gradual immune dysfunction that progress to the acquired immunodeficiency syndrome (AIDS). The infection is associated with a gradual loss of T helper CD4+ populations that is related to AIDS progression. During last years different populations of T helper CD4 T cells named Th1, Th2 and Th17 have been described. These populations produce different patterns of cytokines and express the chemokine receptors CXCR3, CCR4 and CCR6 respectively. In the present work we analyzed levels of CD4+ lymphocytes expressing these chemokine receptors in HIV1-AIDS patients. Two groups of HIV1+ patients were enrolled in our study: Group 1 including 15 individuals with 500 CD4 cells/mm3. A healthy control group (n=7) was also incorporated to the study. Percentages and absolute numbers of CD4+ lymphocytes expressing chemokine receptors (CXCR3, CCR4 and CCR6) were determined by flow cytometry. Patients from Groups 1 and 2 showed significantly decreased values of CD4+CXCR3+ T lymphocyte when compared to healthy control individuals (Group1: 89±17/mm3; Group2: 188±30/mm3; Control: 404±128/mm3; p