Role of reactive oxygen species in the early stages of liver regeneration in streptozotocin-induced diabetic rats

FRANCÉS D. E.; RONCO M. T.; INGARAMO P. I.; MONTI J. A.; PISANI G. B.; PARODY J. P.; PELLEGRINO J. M.; CARRILLO M. C.; MARTÍN-SANZ PALOMA; CARNOVALE C. E.

FREE RADICAL RESEARCH

TAYLOR & FRANCIS LTD

Año: 2011 vol. 45 p. 1143 - 1153

1071-5762

Abstract Diabetes mellitus is a risk factor for prognosis after liver resection. In previous work we found a pro-apoptotic state in the diabetic rat liver. In this work, this was also observed 1 hour post-partial hepatectomy (PH) and resulted in a deficient regenerative response 24 hours post-PH. Treatment with insulin and/or Desferoxamine (DES) (iron chelator) or TEMPOL (TEM) (free radicals scavenger) were effective in preventing the liver reactive oxygen species (ROS) production induced by diabetic state. High levels of ROS play a role in hepatic lipid peroxidation in diabetes before and after PH, and lead to increased pro-apoptotic events, which contribute to a reduced regenerative response. This becomes of relevance for the potential use of antioxidants/free radical scavengers plus insulin for improvement of post-surgical recovery of diabetic patients subjected to a partial hepatectomy.