Chia Oil preventive therapy administered by oral route to a Parkinsonian rat model.

NARANJO A; JÁVEGA COMETTO; CHAMPARINI L; HEREÑU C; CRESPO R

Congreso; XXXVIII Annual Meeting of the SAN; 2023

Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons causing motor and non-motor symptoms. Chia oil (CO) contains α-linolenic acid (ALA) with antioxidant and anti-inflammatory effects. The aim of this work was to investigate the effect of CO on the PD 6-OHDA neurodegeneration rat model, by assessing behavioral alterations, clinical and histological parameters. CO composition was analyzed by CG-MS showing a 63% of ALA content. 2-month-old male Wistar rats were injected with 6-OHDA or vehicle through stereotaxic surgery (week 0). CO (1g/kg/day) was orally administered for 1 week prior to the 6-OHDA administration (week -1) and for 4 weeks after. Behavioral tests analysis showed that CO does not modify anxiety parameters but improves cognitive ones. The animal weights and their water/food intake decreased the day after surgery and increased normally afterwards. Physiological parameters were measured in feces, urine, cerebrospinal fluid and serum without significant changes in urine volume, osmolarity and protein content. No toxicological effect was found in liver parameters. Liver, aorta, brain, kidney and small intestine did not show any morphological changes by histological analysis. We conclude that CO treatment did not affect physiological parameters and is a great source of ALA that prevents or decreases neurodegenerative processes and cognitive impairment induced by 6OHDA in the parkinsonian model.