INVESTIGADORES
CRESPO Rosana
artículos
Título:
Phytochemicals as estrogen receptor modulators?a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
Autor/es:
HEREÑU C; CRESPO R
Revista:
Translational Cancer Research
Editorial:
AME Publishing Company
Referencias:
Año: 2023
ISSN:
2219-6803
Resumen:
The proposed model for mechanismsof action involved in C. reticulata and P. ternata-inducedNSCLC growth inhibition would be the modulation of thenuclear receptor (ESR1)co-repressor (NCOA3) complexin control of cell cycle via c-Fos transcription factor.As concluding remarks, the antiproliferative effectof phytocompounds from medicinal plants throughthe modulation of ERs, specifically in lung cells, is apromising mechanism of action that could provide scientific information to find new therapeutic targets.
